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It may be my previous bias thinking it was a phenotype of h142 that makes me say this, but after smoking the puros of each variety my tongue is telling me that the sweet flavor on the tale end of the burley dominant flavor of h142 is what I'm going to refer of as BigBonners Big Havana

However Glendinning et al 2001 find only a small peripheral desensitization for salicin, concluding that Schoonhoven erred, and that habituation in this case is centrally mediated

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I have written more extensively on this

Here, the vital exchange of gases occurs: life-giving oxygen passes into the bloodstream, while carbon dioxide, a waste product, is moved from the blood into the alveoli to be exhaled